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Warfarin's less strong R-enantiomer is metabolized in part by CYP3A4 (and also CYP1A2 and CYP2C19). Watch INR additional commonly if coadministered with inhibitors of such isoenzymes and change warfarin dose if essential.No unique dose adjustment advisable when tofacitinib coadministered with potent CYP2C19 inhibitors; lower tofacitinib dose if coa

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